Fenbendazole was originally developed to treat parasites, and has also shown to help fight tumor growth. Multiple peer-reviewed studies have shown that this anthelmintic drug can help reduce the size of tumors and stop cancer cells from growing. This drug can be found without a prescription at most medical establishments, and it is quite inexpensive. However, it is important to discuss taking this drug with a doctor first, as there are some supplements that may interfere with the effectiveness of this medication.
The benzimidazole family of drugs, including fenbendazole, works by disrupting the formation of microtubules within cells. This is similar to the actions of other anticancer agents, such as colchicine and other vinca alkaloids. Fenbendazole is able to interact with a specific location on the tubulin protein, which is a key component of the cell’s spindle assembly apparatus. This interaction results in a destabilization of the microtubules, which is an essential part of the process that allows chemotherapy to kill cancer cells.
This drug can be used to augment the effects of many different types of chemotherapy, as well as radiation. It can be used in conjunction with other drugs that act as microtubule stabilizers, such as the vinca alkaloids and the hypoxia-selective nitroheterocyclic cytotoxins and radiosensitizers. In fact, several studies have shown that combining fenbendazole with these other medications can improve the survival rate of patients who are diagnosed with cancer.
For example, a recent study showed that fenbendazole was able to enhance the effectiveness of paclitaxel in cancer patients with metastatic breast cancer. This is because fenbendazole was a natural inhibitor of mitosis, which helps paclitaxel target cancer cells more effectively. This combination treatment resulted in a significant increase in the percentage of patients who survived for up to six months after their diagnosis.
Another study tested the effects of fenbendazole in mice with metastatic prostate cancer. The mice were treated with a regimen that included three daily injections of fenbendazole or a placebo. The researchers found that fenbendazole was significantly more effective at stopping the spread of the tumor than the placebo. In addition, the fenbendazole-treated mice had fewer metastases in the lung and less bone damage than the control mice.
Fenbendazole can also help to reduce the toxicity of other anticancer drugs, such as docetaxel. In the experiments described above, cultures were made hypoxic by sealing the bottles with rubber gaskets and inserting needles for influx and efflux of gases. The cultures were then treated for 2 h with graded doses of docetaxel, and relative surviving fractions were calculated by comparing the clonogenicity of untreated controls with the clonogenicity of cultured cells exposed to docetaxel plus fenbendazole. The survival curves for the two drugs are superimposed on the graph, showing that fenbendazole increased the sensitivity of cultured cells to docetaxel. fenbendazole for humans